Hypothermia reduces the propensity of cortical tissue to propagate direct current depolarizations in the rat.

@article{Takaoka1996HypothermiaRT,
  title={Hypothermia reduces the propensity of cortical tissue to propagate direct current depolarizations in the rat.},
  author={Seiji Takaoka and Robert D. Pearlstein and David Sjoquist Nick Warner},
  journal={Neuroscience letters},
  year={1996},
  volume={218 1},
  pages={25-8}
}
Both spreading depression (SD) and spontaneous cortical ischemic depolarizations are known to be sensitive to brain temperature. What is unknown is whether this temperature effect is caused by altered sensitivity of cortical tissue to the initiating stimulus or is attributable to an altered ability of cortex to propagate the depolarization wave. To address this, halothane anesthetized rats underwent surface heating/cooling to produce pericranial temperatures of 33 degrees C, 38 degrees C, or 40… CONTINUE READING