Hypothermia reduces early hypoperfusion and metabolic alterations during the acute phase of massive subarachnoid hemorrhage: a laser-Doppler-flowmetry and microdialysis study in rats.

@article{Schubert2008HypothermiaRE,
  title={Hypothermia reduces early hypoperfusion and metabolic alterations during the acute phase of massive subarachnoid hemorrhage: a laser-Doppler-flowmetry and microdialysis study in rats.},
  author={G A Schubert and S. C. L. de Poli and Aminadav Mendelowitsch and Lothar Schilling and C. Thom{\'e}},
  journal={Journal of neurotrauma},
  year={2008},
  volume={25 5},
  pages={539-48}
}
Morbidity and mortality of subarachnoid hemorrhage (SAH) are correlated with the severity of the patient's acute neurological deficit. This initial presentation has been attributed to cerebral hypoperfusion in the acute phase, and we investigated the impact of moderate hypothermia on the early changes in perfusion and metabolism following massive experimental SAH. SAH was induced in 61 anesthetized rats by rapid injection of 0.5 mL of arterial blood into the cisterna magna. In normothermia (NT… CONTINUE READING
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