Hypothermia for 24 Hours After Asphyxic Cardiac Arrest in Piglets Provides Striatal Neuroprotection That Is Sustained 10 Days After Rewarming

@article{Agnew2003HypothermiaF2,
  title={Hypothermia for 24 Hours After Asphyxic Cardiac Arrest in Piglets Provides Striatal Neuroprotection That Is Sustained 10 Days After Rewarming},
  author={Dawn Mueller Agnew and Raymond C Koehler and Anne-Marie Guerguerian and Donald H. Shaffner and Richard J. Traystman and Lee J. Martin and Rebecca N. Ichord},
  journal={Pediatric Research},
  year={2003},
  volume={54},
  pages={253-262}
}
The neuroprotective effect of hypothermia instituted after resuscitation from asphyxic cardiac arrest has not been studied in immature brain, particularly in a large animal model with recovery periods greater than 4 d. Moreover, protection from severe hypoxia seen with 3 h of hypothermia was reported to be lost when hypothermic duration was extended to 24 h in unsedated piglets, in contrast to the neuroprotection reported by 72 h of intrauterine head cooling in fetal sheep. Piglets (5–7… CONTINUE READING

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Neurodevelopmen - tal outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia

  • AJ Gunn, PD Gluckman, TR Gunn
  • Pediatrics
  • 2001

Sedation and paralysis after cardiac arrest in piglets delays EEG recovery and is associated with improved short-term neurologic outcome

  • RN Ichord, DM Agnew, RC Koehler, RJ Traystman
  • Abstr Soc Neurosci
  • 2001

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