Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin

@article{Bissette1976HypothermiaAI,
  title={Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin},
  author={Garth Bissette and Charles B. Nemeroff and Peter Thomas Loosen and Arthur J. Prange and Morris A. Lipton},
  journal={Nature},
  year={1976},
  volume={262},
  pages={607-609}
}
NEUROTENSIN is a tridecapeptide (pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu–COOH)1 isolated from bovine hypothalami2. Using a sensitive and specific radio immunoassay, Carraway and Leeman have demonstrated immunoreactive neurotensin in hypothalamic extracts of rat, mouse, rabbit and human tissue3. Intravenous (i.v.) administration of neurotensin to rats has been reported to cause hypotension (minimum effective dose 100 pmol kg−1 = 0.167 µg kg−1), cyanosis (minimum effective dose 1… CONTINUE READING
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