Hypothermia Attenuates β1 Integrin Expression on Extravasated Neutrophils in an Animal Model of Meningitis


Brain injury in meningitis occurs in part as a consequence of leukocyte migration and activation. Leukocyte integrins are pivotal in the inflammatory response by mediating adhesion to vascular endothelium and extracellular matrix proteins. We have demonstrated that moderate hypothermia early in the course of meningitis decreases leukocyte sequestration… (More)
DOI: 10.1023/A:1011044312536


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