Hypothalamus-pituitary-ovarian axis in cyclic rats lacking progesterone actions.

@article{SnchezCriado1993HypothalamuspituitaryovarianA,
  title={Hypothalamus-pituitary-ovarian axis in cyclic rats lacking progesterone actions.},
  author={Jos{\'e} Eugenio S{\'a}nchez-Criado and F Galiot and Carmina Bellido and Dolores Gonzalez and M Angeles T{\'e}bar},
  journal={Biology of reproduction},
  year={1993},
  volume={48 4},
  pages={916-25}
}
Antagonizing diestrous progesterone actions in cyclic rats by s.c. injections of the antiprogesterone RU486 (2 mg twice a day from metestrus through proestrus) increased LH and decreased FSH basal serum concentrations. Ovariectomy at metestrus (0800 h) increased serum levels of both gonadotropins in controls and reversed the RU486-induced dissociation of basal gonadotropin secretion. RU486-dissociated gonadotropin secretion is also dependent upon LHRH, since treatment (s.c.) with 1 mg GnRH… CONTINUE READING
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