Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease

@inproceedings{Petrescu2018HypothalamusPituitaryAdrenalDI,
  title={Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease},
  author={Anca D. Petrescu and Jessica Kain and Victoria Liere and Trace Heavener and Sharon DeMorrow},
  booktitle={Front. Endocrinol.},
  year={2018}
}
The Hypothalamic-Pituitary-Adrenal (HPA) axis has an important role in maintaining the physiological homeostasis in relation to external and internal stimuli. The HPA axis dysfunctions were extensively studied in neuroendocrine disorders such as depression and chronic fatigue syndrome but less so in hepatic cholestasis, cirrhosis or other liver diseases. The HPA axis controls many functions of the liver through neuroendocrine forward signaling pathways as well as negative feedback mechanisms… CONTINUE READING
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