Hypothalamus–Pituitary–Thyroid Feedback Control: Implications of Mathematical Modeling and Consequences for Thyrotropin (TSH) and Free Thyroxine (FT4) Reference Ranges

@article{Goede2014HypothalamusPituitaryThyroidFC,
  title={Hypothalamus–Pituitary–Thyroid Feedback Control: Implications of Mathematical Modeling and Consequences for Thyrotropin (TSH) and Free Thyroxine (FT4) Reference Ranges},
  author={S. Goede and M. Leow and J. Smit and H. Klein and Johannes W. Dietrich},
  journal={Bulletin of Mathematical Biology},
  year={2014},
  volume={76},
  pages={1270-1287}
}
The components of thyrotropic feedback control are well established in mainstream physiology and endocrinology, but their relation to the whole system’s integrated behavior remains only partly understood. Most modeling research seeks to derive a generalized model for universal application across all individuals. We show how parameterizable models, based on the principles of control theory, tailored to the individual, can fill these gaps. We develop a system network describing the closed-loop… Expand
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