Hypothalamo-Sympathetic Modulation of Splenic Natural Killer Cell Activity : An Involvement of Brain Cytokines

@inproceedings{Katafuchi2011HypothalamoSympatheticMO,
  title={Hypothalamo-Sympathetic Modulation of Splenic Natural Killer Cell Activity : An Involvement of Brain Cytokines},
  author={Toshihiko Katafuchi},
  year={2011}
}
The sympathetic nervous system is one of the multiple channels that communicate between brain and immune system. In the brain-immune interactions, cytokines produced in the periphery and brain during inflammatory as well as noninflammatory stress play important roles as signal molecules. For example, central administration of interleukin-1 (IL-1 ) and interferon(IFN) suppresses splenic natural killer (NK) cell activity in rats, which is mediated by, at least in part, the sympathetic… CONTINUE READING