Hypothalamic sites responding to predator threats – the role of the dorsal premammillary nucleus in unconditioned and conditioned antipredatory defensive behavior

@article{Cezrio2008HypothalamicSR,
  title={Hypothalamic sites responding to predator threats – the role of the dorsal premammillary nucleus in unconditioned and conditioned antipredatory defensive behavior},
  author={Anne Fabelly Ramalho Cez{\'a}rio and {\'E}rika Renata Ribeiro-Barbosa and Marcus Vin{\'i}cius Chrys{\'o}stomo Baldo and Newton Sabino Canteras},
  journal={European Journal of Neuroscience},
  year={2008},
  volume={28}
}
In this study we provide a comprehensive analysis of the hypothalamic activation pattern during exposure to a live predator or an environment previously associated with a predator. Our results support the view that hypothalamic processing of the actual and the contextual predatory threats share the same circuit, in which the dorsal premammillary nucleus (PMd) plays a pivotal role in amplifying this processing. To further understand the role of the PMd in the circuit organizing antipredatory… Expand
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Evidence for the thalamic targets of the medial hypothalamic defensive system mediating emotional memory to predatory threats
TLDR
Investigation of the role of the dorsal premammillary nucleus's main thalamic targets in both unconditioned and conditioned defensive behaviors suggests that the PMd seems to be critically involved in the emotional memory processing related to predator cues. Expand
The periaqueductal gray and its potential role in maternal behavior inhibition in response to predatory threats
TLDR
The dual role of the periaqueductal gray is confirmed, where, in the present case, the dorsal PAG, apart from organizing defensive responses, also appears to account for the behavioral inhibition of non-defensive responses. Expand
A role for the anteromedial thalamic nucleus in the acquisition of contextual fear memory to predatory threats
TLDR
Inactivating the rat AMv with muscimol either prior to cat exposure or prior to exposure to the cat-related context did not interfere with innate fear responses, but it drastically reduced contextual conditioning to the predator-associated environment. Expand
Blockade of NMDA or NO in the dorsal premammillary nucleus attenuates defensive behaviors
TLDR
The results showed that both AP7 and NP significantly attenuated the behavioral responses induced by the live cat, suggesting that the NMDA/NO pathway plays an important role in the Behavioral responses mediated by the PMd. Expand
Acquisition of Pavlovian Fear Conditioning Using β-Adrenoceptor Activation of the Dorsal Premammillary Nucleus as an Unconditioned Stimulus to Mimic Live Predator-Threat Exposure
TLDR
It is found that PMd β-1 adrenergic stimulation is a good model to mimic predatory threat-induced internal state changes, and works as a US able to mobilize the same systems involved in the acquisition and expression of predator-related contextual conditioning. Expand
A study of the catecholaminergic inputs to the dorsal premammillary nucleus
TLDR
Evidence suggests that the locus coeruleus is seemingly a part of the circuit responding to predatory threats, and, as shown by the present results, is the sole source of catecholaminergic inputs to the PMd, providing noradrenergic Inputs to the nucleus, which, by acting via beta adrenoceptor, seems to be critical for the expression of anti-predatory responses. Expand
Revealing a Cortical Circuit Responsive to Predatory Threats and Mediating Contextual Fear Memory.
TLDR
The present findings suggest that predator threat has an extensive representation in the cerebral cortex and revealed a cortical network that is responsive to predatory threats and exerts a critical role in processing fear memory. Expand
The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats
TLDR
The results revealed that the anterior cingulate area is involved in both the acquisition and expression of contextual fear to predatory threat, and can provide predictive relationships between the context and the predator threat. Expand
Sensing danger through the olfactory system: The role of the hypothalamic dorsal premammillary nucleus
TLDR
It is shown that the dorsal premammillary nucleus is involved in the conditioned defensive responses to the shock-paired coffee odor and the contextual response to the associated environment. Expand
The ventromedial hypothalamus mediates predator fear memory
TLDR
It is demonstrated that neural activity in the VMHdm is required for both the acquisition and recall of predator fear memory, whereas that of its downstream effector, the dorsal periaqueductal grey, is required only for the acute expression of fear. Expand
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References

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TLDR
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