Pyatnitskaya, Clinical Aspects of Narcotics [in Russian
- N. L
Rats with lateral hypothalamic self-stimulation (SS) were given morphine injections twice a day for 15 days in doses rising from 20 to 120 mg/kg. Morphine facilitated SS starting with the 9th injection. Short-term (16–18 h) withdrawal of the narcotic from the rats or its discontinuation led to inhibition of SS. Complete suppression of SS was observed after injection of the morphine antagonist nalorphine in a dose of 5 mg/kg.