Hypothalamic self-stimulation in morphine-dependent rats during the abstinence syndrome

Abstract

Rats with lateral hypothalamic self-stimulation (SS) were given morphine injections twice a day for 15 days in doses rising from 20 to 120 mg/kg. Morphine facilitated SS starting with the 9th injection. Short-term (16–18 h) withdrawal of the narcotic from the rats or its discontinuation led to inhibition of SS. Complete suppression of SS was observed after injection of the morphine antagonist nalorphine in a dose of 5 mg/kg.

DOI: 10.1007/BF00801347

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Cite this paper

@article{Zvartau2004HypothalamicSI, title={Hypothalamic self-stimulation in morphine-dependent rats during the abstinence syndrome}, author={Edwin E. Zvartau}, journal={Bulletin of Experimental Biology and Medicine}, year={2004}, volume={85}, pages={321-324} }