Hypothalamic resistin induces hepatic insulin resistance.

  title={Hypothalamic resistin induces hepatic insulin resistance.},
  author={Evan D Muse and Tony K. T. Lam and Phillip E Scherer and Luciano Rossetti},
  journal={The Journal of clinical investigation},
  volume={117 6},
Circulating resistin stimulates endogenous glucose production (GP). Here, we report that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine expression in the liver. The infusion of either resistin or an active cysteine mutant in the third cerebral ventricle (icv) or in the mediobasal hypothalamus stimulated GP independent of changes in circulating levels of glucoregulatory hormones. Conversely, central antagonism of resistin action… CONTINUE READING


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