Hypothalamic regulation of sleep and circadian rhythms

  title={Hypothalamic regulation of sleep and circadian rhythms},
  author={C. Saper and T. Scammell and J. Lu},
  • C. Saper, T. Scammell, J. Lu
  • Published 2005
  • Biology, Medicine
  • Nature
  • A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These… CONTINUE READING
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