Hypothalamic regulation of sleep and circadian rhythms

@article{Saper2005HypothalamicRO,
  title={Hypothalamic regulation of sleep and circadian rhythms},
  author={Clifford B. Saper and Thomas E. Scammell and Jun Lu},
  journal={Nature},
  year={2005},
  volume={437},
  pages={1257-1263}
}
A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These… 
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