Hypothalamic regulation of sleep and circadian rhythms

  title={Hypothalamic regulation of sleep and circadian rhythms},
  author={Clifford B. Saper and Thomas E. Scammell and Jun Lu},
A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These… 

Functional neuroanatomy of sleep and circadian rhythms

Basic Circadian Timing and Sleep-Wake Regulation

This chapter describes the basic circadian timing and its main properties, and reviews the mechanisms by which the circadian system controls different aspects related to sleep and wakefulness.

Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback

The authors describe the hypothalamic circuitry for the integration of photic and nonphotic environmental time cues and how this integration allows organisms to sculpt patterns of rest-activity and sleep-wake cycles that are optimally adaptive.

Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness.

Mutual influence of sleep and circadian clocks on physiology and cognition

Hypothalamic Control of Sleep in Aging

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  • Psychology, Biology
    NeuroMolecular Medicine
  • 2012
The role of the hypothalamus in the regulation of sleep is discussed also in the context of aging, which is associated with changes in both hypothalamic function and the composition of sleep.

Circadian regulation of sleep in mammals

  • T. Deboer
  • Biology, Psychology
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The sleep switch: hypothalamic control of sleep and wakefulness

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The necessary elements for a circuit that provides circadian regulation of arousal are described and mechanisms for regulation of circadian and sleep–waking functions are revealed.

Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms

It is shown that excitotoxic lesions of the DMH reduce circadian rhythms of wakefulness, feeding, locomotor activity, and serum corticosteroid levels by 78-89% while also reducing their overall daily levels.

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The level of EEG slow-wave activity (SWA) is determined by the duration of prior sleep and waking. SWA is a marker of nonREM sleep intensity and may serve as an indicator of sleep homeostasis. The

Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans

  • D.G.M. DijkC. Czeisler
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
Analyses of the (nonadditive) interaction of the circadian and sleep-dependent components of sleep propensity and sleep structure revealed that the phase relation between the sleep-wake cycle and the circadian pacemaker during entrainment promotes the consolidation of sleep and wakefulness and facilitates the transitions between these vigilance states.

The hypothalamic integrator for circadian rhythms

The “Other” Circadian System: Food as a Zeitgeber

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  • Biology
    Journal of biological rhythms
  • 2002
Recent findings concerning the entrainment of clock gene expression in the central nervous system and in peripheral tissues by periodic food access are presented, and the implications of these findings for a better understanding of a circadian system that entrains to meals, rather than to light, are discussed.

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Recent advances provide compelling evidence that narcolepsy may be a neurodegenerative or autoimmune disorder resulting in a loss of hypothalamic neurons containing the neuropeptide orexin (also known as hypocretin).

Behavioral State Instability in Orexin Knock-Out Mice

It is demonstrated that the fragmented wakefulness of orexin deficiency is not a consequence of abnormal sleep homeostasis, poor circadian control, or defective fundamental arousal systems, and may be best described as behavioral state instability, with apparently low thresholds to transition between states.

Cholinergic and noradrenergic modulation of thalamocortical processing