Hypothalamic-pituitary-gonadal function in Anorexia Nervosa and Bulimia

  title={Hypothalamic-pituitary-gonadal function in Anorexia Nervosa and Bulimia},
  author={Michael J. Devlin and B. Timothy Walsh and Jack L. Katz and Steven P. Roose and Daniel M. Linkie and Louise Wright and Raymond L. Vande Wiele and Alexander H. Glassman},
  journal={Psychiatry Research},

Disturbances in gonadal axis in women with anorexia nervosa

This study demonstrates dissociation in the secretion of gonadotropins after hypothalamic stimulation in anorexic patients and reveals the relationship between alterations in the hormones of the HPG axis, not only with the changes in body weight, but also with the duration of the disease.

Disturbances in gonadal axis in women with anorexia nervosa.

Differential dynamic responses of luteinizing hormone to gonadotropin releasing hormone in patients affected by bulimia nervosa-purging versus non-purging type

Even in the absence of overt menstrual distur bances, an altered LH secretion elicited by pulsatile stimulation of endogenous GnRH was found, with a more severe impairment in purging than in non-purging bulimics, possibly related to their greater psychopathological and physical burden.

Decreased serum leptin in bulimia nervosa.

Results are consistent with the hypothesis that decreased leptin function may be associated with alterations in eating patterns, metabolic rate, and neuroendocrine regulation in bulimia nervosa.

Thyroid function in bulimia nervosa

Long-term menstrual and reproductive function in patients with bulimia nervosa.

It is suggested that while menstrual irregularities are common, bulimia nervosa appears to have little impact on later ability to achieve pregnancy.

Update on Endocrine Disturbances in Anorexia Nervosa

An overview of the large body of literature concerning endocrine aspects of anorexia nervosa is provided with the main focus on the latest results, which provide leads for potential etiological theories.

Metabolic abnormalities in bulimia nervosa.

The data suggest that there is a disturbance in energy regulation in bulimia nervosa, but the origins and role of this disturbance in the pathophysiology of bulimic nervosa are unclear.



Body weight and the pituitary response to hypothalamic releasing hormones in patients with anorexia nervosa.

The restoration of a normal body weight is a prerequisite for the resumption of menstruation in women with anorexia nervosa, but other as yet unidentified factors may also be involved.

LHRH Responsiveness in Anorexia Nervosa: Intactness Despite Prepubertal Circadian LH Pattern

Findings provide further evidence for the intactness of pituitary function and for the possibility of a functional hypothalamic disturbance in anorexia nervosa.

Hypothalamic-endocrine dysfunction in anorexia nervosa.

Hormonal alterations in the hypothalamic-pituitary axis in patients with anorexia nervosa probably represent adaptive and protective mechanisms for chronic starvation and weight loss.

Hypothalamic Pituitary Function in Starving Healthy Subjects

If the same endocrine disturbances as in anorexia nervosa can be reproduced in healthy human beings during starvation, the hormonal changes could be considered specific for reduced calorie intake or weight loss rather than for anorexa nervosa.

Low dose pulsatile gonadotropin-releasing hormone in anorexia nervosa: a model of human pubertal development.

The results demonstrate a changing pattern of pituitary response to physiological administration of GnRH and indicate that the changes in gonadotropin secretion during normal puberty are consistent with the effects of the single decapeptide GnRH.

LH and FSH Response to Gonadotropin-Releasing Hormone in Anorexia Nervosa: Effect of Nutritional Rehabilitation1

The LH and FSH responses to the administration of synthetic gonadotropin-releasing hormone (GnRH) were assessed in 14 patients with anorexia nervosa before, during and following weight gain. In 8

Weight and Circadian Luteinizing Hormone Secretory Pattern in Anorexia Nervosa

The adult (mature) circadian LH secretory pattern was not present in women who had partially or totally achieved ideal weight but who otherwise remained symptomatic and the return of menses did not show a simple relationship to weight, fatness, or maturity of LH pattern.

Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.

The demonstration that luteinizing hormone (LH) release from the pituitary is episodic rather than constant raises fundamental questions regarding the physiologic control of pulsatile LH secretion