Hypothalamic-pituitary-gonadal function in Anorexia Nervosa and Bulimia

@article{Devlin1989HypothalamicpituitarygonadalFI,
  title={Hypothalamic-pituitary-gonadal function in Anorexia Nervosa and Bulimia},
  author={Michael J. Devlin and B. Timothy Walsh and Jack L. Katz and Steven P. Roose and Daniel M. Linkie and Louise Wright and Raymond L. Vande Wiele and Alexander H. Glassman},
  journal={Psychiatry Research},
  year={1989},
  volume={28},
  pages={11-24}
}
Patients with anorexia nervosa (AN) exhibit neuroendocrine abnormalities that may result solely from emaciation or may reflect defective endocrine mechanisms which are intrinsic to disordered eating even in the absence of starvation. To distinguish these possibilities, we have studied indices of hypothalamic-pituitary-gonadal (HPG) function in 9 patients with AN, 12 normal weight patients with bulimia and recent or current oligomenorrhea, and 8 normal weight controls. Measurement of 24-hour… 
Disturbances in gonadal axis in women with anorexia nervosa
Anorexia nervosa negatively affects multiple body systems including the reproductive system. AIM To assess the disturbances in the hypothalamic-pituitary-gonadal axis (HPG) and the relationship
Disturbances in gonadal axis in women with anorexia nervosa.
TLDR
This study demonstrates dissociation in the secretion of gonadotropins after hypothalamic stimulation in anorexic patients and reveals the relationship between alterations in the hormones of the HPG axis, not only with the changes in body weight, but also with the duration of the disease.
Differential dynamic responses of luteinizing hormone to gonadotropin releasing hormone in patients affected by bulimia nervosa-purging versus non-purging type
TLDR
Even in the absence of overt menstrual distur bances, an altered LH secretion elicited by pulsatile stimulation of endogenous GnRH was found, with a more severe impairment in purging than in non-purging bulimics, possibly related to their greater psychopathological and physical burden.
Anorexia nervosa and bulimia nervosa
Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by pathological alterations in food intake. These disorders are more common among young females, although they can
Decreased serum leptin in bulimia nervosa.
TLDR
Results are consistent with the hypothesis that decreased leptin function may be associated with alterations in eating patterns, metabolic rate, and neuroendocrine regulation in bulimia nervosa.
Thyroid function in bulimia nervosa
TLDR
Results show a substantial reduction in thyroid hormone levels after 7 weeks of abstinence from binging and vomiting behaviors and a positive correlation between caloric intake and TSH values, suggesting that food binging may stimulate thyroid activity.
Long-term menstrual and reproductive function in patients with bulimia nervosa.
TLDR
It is suggested that while menstrual irregularities are common, bulimia nervosa appears to have little impact on later ability to achieve pregnancy.
Pituitary LH reserve suggests high risk of bulimia in amenorrheic women
TLDR
When facing secondary amenorrheic women at first consultation, low basal plasma LH levels and LH response to GnRH challenge may allow one to suspect the presence of abnormal eating pattern of bulimic type.
Update on Endocrine Disturbances in Anorexia Nervosa
TLDR
An overview of the large body of literature concerning endocrine aspects of anorexia nervosa is provided with the main focus on the latest results, which provide leads for potential etiological theories.
Metabolic abnormalities in bulimia nervosa.
TLDR
The data suggest that there is a disturbance in energy regulation in bulimia nervosa, but the origins and role of this disturbance in the pathophysiology of bulimic nervosa are unclear.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Hypothalamic-pituitary-adrenal-cortical activity in anorexia nervosa and bulimia
TLDR
HPA activity is normal in most patients of normal body weight with bulimia and that the psychological and behavioral disturbances common to both anorexia nervosa and bulimIA are, in the absence of significant weight loss, insufficient to produce major alterations in HPA activity.
Body weight and the pituitary response to hypothalamic releasing hormones in patients with anorexia nervosa.
TLDR
The restoration of a normal body weight is a prerequisite for the resumption of menstruation in women with anorexia nervosa, but other as yet unidentified factors may also be involved.
LHRH Responsiveness in Anorexia Nervosa: Intactness Despite Prepubertal Circadian LH Pattern
TLDR
Findings provide further evidence for the intactness of pituitary function and for the possibility of a functional hypothalamic disturbance in anorexia nervosa.
Hypothalamic-endocrine dysfunction in anorexia nervosa.
TLDR
Hormonal alterations in the hypothalamic-pituitary axis in patients with anorexia nervosa probably represent adaptive and protective mechanisms for chronic starvation and weight loss.
Hypothalamic Pituitary Function in Starving Healthy Subjects
TLDR
If the same endocrine disturbances as in anorexia nervosa can be reproduced in healthy human beings during starvation, the hormonal changes could be considered specific for reduced calorie intake or weight loss rather than for anorexa nervosa.
Low dose pulsatile gonadotropin-releasing hormone in anorexia nervosa: a model of human pubertal development.
TLDR
The results demonstrate a changing pattern of pituitary response to physiological administration of GnRH and indicate that the changes in gonadotropin secretion during normal puberty are consistent with the effects of the single decapeptide GnRH.
LH and FSH Response to Gonadotropin-Releasing Hormone in Anorexia Nervosa: Effect of Nutritional Rehabilitation1
The LH and FSH responses to the administration of synthetic gonadotropin-releasing hormone (GnRH) were assessed in 14 patients with anorexia nervosa before, during and following weight gain. In 8
Weight and Circadian Luteinizing Hormone Secretory Pattern in Anorexia Nervosa
TLDR
The adult (mature) circadian LH secretory pattern was not present in women who had partially or totally achieved ideal weight but who otherwise remained symptomatic and the return of menses did not show a simple relationship to weight, fatness, or maturity of LH pattern.
Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.
The demonstration that luteinizing hormone (LH) release from the pituitary is episodic rather than constant raises fundamental questions regarding the physiologic control of pulsatile LH secretion
Metabolic and endocrine indices of starvation in Bulimia: A comparison with anorexia nervosa
TLDR
Data indicate that many patients with bulimia showed the metabolic signs of starvation at the time of the study, a finding supported by the symptoms of endocrine adaptation to starvation, namely low triiodothyronine and a decreased noradrenaline response to an orthostatic test in many of these patients.
...
1
2
3
4
5
...