Hypothalamic pituitary dysfunction amongst nasopharyngeal cancer survivors

@article{Ratnasingam2014HypothalamicPD,
  title={Hypothalamic pituitary dysfunction amongst nasopharyngeal cancer survivors},
  author={Jeyakantha Ratnasingam and Nabeela Karim and Sivasinthujah Paramasivam and Lobna Yassin Ibrahim and L. L. Lim and Alexander Tong Boon Tan and Shireene Ratna Vethakkan and Asep Jalaludin and Suk Ping Chan},
  journal={Pituitary},
  year={2014},
  volume={18},
  pages={448-455}
}
PurposeRadiation fields for nasopharyngeal cancer (NPC) include the base of skull, which places the hypothalamus and pituitary at risk of damage. We aimed to establish the prevalence, pattern and severity of hypothalamic pituitary (HP) dysfunction amongst NPC survivors.MethodsWe studied 50 patients (31 males) with mean age 57 ± 12.2 years who had treatment for NPC between 3 and 21 years (median 8 years) without pre-existing HP disorder from other causes. All patients had a baseline cortisol… CONTINUE READING
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