Hypothalamic-pituitary-adrenal function.

  title={Hypothalamic-pituitary-adrenal function.},
  author={Stafford L. Lightman and Richard J. Windle and X Ma and Michael S. Harbuz and Nola M Shanks and Michael D. Julian and Susan A. Wood and Yvonne M. Kershaw and Colin David Ingram},
  journal={Archives of physiology and biochemistry},
  volume={110 1-2},
Basal hypothalamic-pituitary-adrenal (HPA) function is characterised by pulses of corticosterone secretion followed by a transient refractory period when the axis appears to be inhibited. In females pulses of corticosterone secretion occur approximately once per hour with variation in pulse amplitude underlying a diurnal rhythm. Males show smaller pulses of secretion which become widely spaced during the early light phase nadir. Pulsatility is altered by genetic programming, early life… CONTINUE READING


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