Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence.

@article{Adinoff1990HypothalamicpituitaryadrenalAF,
  title={Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence.},
  author={Bryon Adinoff and Peter R. Martin and George H. A. Bone and Michael J. Eckardt and L Roehrich and David Ted George and H. Moss and Robert L. Eskay and Markku Linnoila and Philip W. Gold},
  journal={Archives of general psychiatry},
  year={1990},
  volume={47 4},
  pages={325-30}
}
We assessed the plasma corticotropin (adrenocorticotropic hormone) and cortisol responses to ovine corticotropin releasing hormone (oCRH) and the cerebrospinal fluid levels of CRH and corticotropin in alcoholics at various durations of abstinence and compared these variables with age-equivalent controls. Alcoholics who were tested at 1 week of abstinence (n = 11) demonstrated a significantly attenuated corticotropin response to oCRH compared with their response at 3 weeks of abstinence. Nine of… CONTINUE READING