Hypothalamic-pituitary-adrenal axis function in children with attention-deficit hyperactivity disorder.

@article{Kaneko1993HypothalamicpituitaryadrenalAF,
  title={Hypothalamic-pituitary-adrenal axis function in children with attention-deficit hyperactivity disorder.},
  author={Masatoki Kaneko and Yutaka Hoshino and Satoko Hashimoto and Tadao Okano and Hisashi Kumashiro},
  journal={Journal of autism and developmental disorders},
  year={1993},
  volume={23 1},
  pages={59-65}
}
Examined hypothalamic-pituitary-adrenal axis (HPA axis) function in 30 children with attention-deficit hyperactivity disorder (ADHD) by measuring the diurnal variation and response to the dexamethasone suppression test (DST) of saliva cortisol. Normal diurnal saliva cortisol rhythm was found in only 43.3% of the ADHD children. DST showed suppression in 46.7% of the ADHD children. An abnormal diurnal rhythm and nonsuppression to the DST were more frequent in the severely hyperactive group than… CONTINUE READING
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