Hypothalamic-pituitary-adrenal axis function after inhaled corticosteroids: unreliability of urinary free cortisol estimation.

@article{Fink2002HypothalamicpituitaryadrenalAF,
  title={Hypothalamic-pituitary-adrenal axis function after inhaled corticosteroids: unreliability of urinary free cortisol estimation.},
  author={Richard S Fink and Lisa N Pierre and Peter T. Daley-Yates and David H Richards and A. Gibson and John William Honour},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 10},
  pages={4541-6}
}
Free cortisol in the urine (UFC) is frequently measured in clinical research to assess whether inhaled corticosteroids (ICS) cause suppression of the hypothalamic-pituitary-adrenal axis. Thirteen healthy male subjects received single inhaled doses (of molar equivalence) of fluticasone propionate (FP), triamcinolone acetonide (TAA), budesonide (BUD), and placebo in this single blind, randomized, cross-over study. UFC output was measured using four commercial immunoassays in samples collected in… CONTINUE READING
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