Hypothalamic-pituitary-adrenal axis dysregulation in dysphoric children and adolescents: cortisol reactivity to psychosocial stress from preschool through middle adolescence.

@article{Hankin2010HypothalamicpituitaryadrenalAD,
  title={Hypothalamic-pituitary-adrenal axis dysregulation in dysphoric children and adolescents: cortisol reactivity to psychosocial stress from preschool through middle adolescence.},
  author={Benjamin L. Hankin and Lisa S. Badanes and John R. Z. Abela and Sarah Enos Watamura},
  journal={Biological psychiatry},
  year={2010},
  volume={68 5},
  pages={484-90}
}
BACKGROUND Most depressed adults exhibit dysregulation of the hypothalamic-pituitary-adrenal axis, including cortisol hyperreactivity to psychosocial challenge. In contrast, remarkably little is known about hypothalamic-pituitary-adrenal axis activity in response to psychosocial challenge among at-risk children and adolescents. This study examined cortisol response to psychosocial challenge in nondepressed, at-risk, dysphoric and nondysphoric control youth across different developmentally… CONTINUE READING
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