Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels.

@article{Dimopoulou2004HypothalamicpituitaryadrenalAD,
  title={Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels.},
  author={Ioanna Dimopoulou and Stylianos Tsagarakis and Andreas T. Kouyialis and Paraskevi P Roussou and Georgios Assithianakis and Marietta Christoforaki and Ioannis Ilias and Damianos E. Sakas and Nikolaos Thalassinos and Charalambos Roussos},
  journal={Critical care medicine},
  year={2004},
  volume={32 2},
  pages={404-8}
}
OBJECTIVE To investigate hypothalamic-pituitary-adrenal axis function in patients requiring mechanical ventilation for traumatic brain injury and to assess the relation of hypothalamic-pituitary-adrenal axis abnormalities with vasopressor dependence and peripheral cytokine levels. DESIGN Prospective study. SETTING General intensive care unit in a university teaching hospital. PATIENTS Forty patients (33 men and 7 women) with moderate to severe traumatic brain injury (mean age, 37 +/- 16… CONTINUE READING

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