Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion.

@article{Mastorakos1994HypothalamicpituitaryadrenalAA,
  title={Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion.},
  author={George P Mastorakos and Jeffery S Weber and Maria Alexandra Magiakou and Hal Gunn and George P. Chrousos},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={79 4},
  pages={934-9}
}
We recently demonstrated that sc administered interleukin-6 (IL-6) strongly stimulates the human hypothalamic-pituitary-adrenal (HPA) axis, with mild toxicity and no hypotensive effects. In this study, we evaluated the response of the human HPA axis to escalating iv doses of recombinant IL-6 in six patients with cancer and good performance status who received daily, every 8 h, three equal doses of 0.3-30 micrograms/kg IL-6. The plasma levels of IL-6 assayed by a specific enzyme-linked… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

Similar Papers

Loading similar papers…