Hypothalamic-pituitary-adrenal alterations in PTSD: are they relevant to understanding cortisol alterations in cancer?

@article{Yehuda2003HypothalamicpituitaryadrenalAI,
  title={Hypothalamic-pituitary-adrenal alterations in PTSD: are they relevant to understanding cortisol alterations in cancer?},
  author={Rachel Yehuda},
  journal={Brain, behavior, and immunity},
  year={2003},
  volume={17 Suppl 1},
  pages={S73-83}
}
Recent studies of hypothalamic-pituitary-adrenal axis alterations in PTSD have demonstrated a specific type of hyperresponsivity of this stress hormonal system characterized by a greater negative feedback inhibition of cortisol, which may paradoxically serve to lower cortisol levels. The occurrence of cancer has been recently described by many investigators as an event that fulfills the DSM-IV criteria for a "traumatic event" that has been demonstrated in some cases to be linked with the… CONTINUE READING