Hypothalamic neuropeptide mechanisms for regulating energy balance: from rodent models to human obesity.

@article{Mercer2001HypothalamicNM,
  title={Hypothalamic neuropeptide mechanisms for regulating energy balance: from rodent models to human obesity.},
  author={Julian G Mercer and John R Speakman},
  journal={Neuroscience and biobehavioral reviews},
  year={2001},
  volume={25 2},
  pages={101-16}
}
In small rodents there is compelling evidence of a lipostatic system of body mass regulation in which peripheral signals of energy storage are decoded in the hypothalamus. The ability of small mammals to defend an appropriate mass against imposed energy imbalance has implicated hypothalamic neuroendocrine systems in body mass regulation. The effect of the neuropeptide systems involved in this regulation is primarily compensatory. However, small mammals can also effect changes in the level of… CONTINUE READING

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