Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain.

@article{Itateyama2003HypothalamicNH,
  title={Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain.},
  author={Emi Itateyama and Seiichi Chiba and Toshiie Sakata and Hironobu Yoshimatsu},
  journal={Experimental biology and medicine},
  year={2003},
  volume={228 10},
  pages={
          1132-7
        }
}
Leptin regulates feeding behavior and energy metabolism by affecting hypothalamic neuromodulators. The present study was designed to examine hypothalamic neuronal histamine, a recently identified mediator of leptin signaling in the brain, in genetic obese animals. Concentrations of hypothalamic histamine and tele-methylhistamine (t-MH), a major histamine metabolite, were significantly lower in obese (ob/ob) and diabetic (db/db) mice, and Zucker fatty (fa/fa) rats, leptin-deficient and leptin… CONTINUE READING
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