Hypothalamic melanocortin signaling and leptin resistance—Perspective of therapeutic application for obesity-diabetes syndrome

@article{Masuzaki2009HypothalamicMS,
  title={Hypothalamic melanocortin signaling and leptin resistance—Perspective of therapeutic application for obesity-diabetes syndrome},
  author={Hiroaki Masuzaki and Tomohiro Tanaka and Ken Ebihara and Kiminori Hosoda and Kazuwa Nakao},
  journal={Peptides},
  year={2009},
  volume={30},
  pages={1383-1386}
}
The adipocyte-derived hormone, leptin controls feeding behavior, augments fatty acid beta-oxidation in the skeletal muscle, attenuates insulin secretion but enhances whole body insulin sensitivity and glucose disposal, thereby serving as a promising therapeutic candidate for the treatment of insulin resistance and dyslipidemia. Along with other researchers, we demonstrated the clinical efficacy and safety of leptin in the treatment of diabetes and dyslipidemia for patients with generalized… Expand
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