Hypothalamic melanin-concentrating hormone and estrogen-induced weight loss.

  title={Hypothalamic melanin-concentrating hormone and estrogen-induced weight loss.},
  author={Paul Mystkowski and Randy J Seeley and Tina M. Hahn and Denis G. Baskin and P. Havel and Alvin M. Matsumoto and Charles W Wilkinson and K A Peacock-Kinzig and Kim Blake and Michael J. Schwartz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 22},
Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that MCH neurons may represent a specific LHA pathway that, when inhibited, contributes to the pathogenesis of certain anorexia syndromes. To test this hypothesis, we measured behavioral, hormonal, and hypothalamic neuropeptide responses in two models of hyperestrogenemia in male rats… CONTINUE READING


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Toward a new neurobiology of energy balance, appetite, and obesity: the anatomists weigh in.

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