Hypothalamic mTOR Signaling Regulates Food Intake

@article{Cota2006HypothalamicMS,
  title={Hypothalamic mTOR Signaling Regulates Food Intake},
  author={D. Cota and K. Proulx and Kathi Smith and S. Kozma and G. Thomas and S. Woods and R. Seeley},
  journal={Science},
  year={2006},
  volume={312},
  pages={927 - 930}
}
  • D. Cota, K. Proulx, +4 authors R. Seeley
  • Published 2006
  • Biology, Medicine
  • Science
  • The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that regulates cell-cycle progression and growth by sensing changes in energy status. We demonstrated that mTOR signaling plays a role in the brain mechanisms that respond to nutrient availability, regulating energy balance. In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with neuropeptide Y and proopiomelanocortin neurons in the arcuate nucleus… CONTINUE READING
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