Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans

@article{Kullmann2017HypothalamicIR,
  title={Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans},
  author={S. Kullmann and A. Fritsche and R. Wagner and S. Schwab and M. Heni},
  journal={Physiology \& Behavior},
  year={2017},
  volume={176},
  pages={134-138}
}
CONTEXT Activity of the hypothalamus - the major brain area controlling peripheral metabolism - is specifically modulated by insulin. Research in animals suggests that brain insulin action influences pancreatic insulin secretion. OBJECTIVE We investigated the association between hypothalamic insulin sensitivity and pancreatic insulin secretion in humans. DESIGN AND SETTING This was a clinical-experimental trial in an university hospital setting. PARTICIPANTS 48 healthy volunteers (21… Expand
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