Hypothalamic inflammation in obesity and metabolic disease.

  title={Hypothalamic inflammation in obesity and metabolic disease.},
  author={Alexander Jais and Jens C. Br{\"u}ning},
  journal={The Journal of clinical investigation},
  volume={127 1},
Over the last years, hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae. There is accumulating evidence that this inflammation not only impairs energy balance but also contributes to obesity-associated insulin resistance. Elevated activation of key inflammatory mediators such as JNK and IκB kinase (IKK) occurs rapidly upon consumption of a high-fat diet, even prior to significant weight gain. This activation of hypothalamic inflammatory… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 139 references

Genetic studies of body mass index yield new insights for obesity

  • AE Locke
  • biology. Nature
  • 2015
1 Excerpt

Similar Papers

Loading similar papers…