Hypothalamic implants of dilute estradiol fail to reduce feeding in ovariectomized rats.

@article{Hrupka2002HypothalamicIO,
  title={Hypothalamic implants of dilute estradiol fail to reduce feeding in ovariectomized rats.},
  author={Brian J Hrupka and Gerard P. Smith and Nori Geary},
  journal={Physiology & behavior},
  year={2002},
  volume={77 2-3},
  pages={233-41}
}
To investigate further the site where estradiol (E(2)) inhibits food intake, we tested the effects on feeding of subcutaneous and intrahypothalamic implants of 10% E(2) benzoate in cholesterol (CHOL) or CHOL alone. E(2) was implanted subcutaneously in Silastic tubes, and intrahypothalamically via bilateral 29-gauge cannulas into the paraventricular nucleus (PVN) or the medial preoptic area (MPA) of ovariectomized (OVX) Sprague-Dawley and Long-Evans rats. Three-day implant periods followed 3-day… CONTINUE READING

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