Hypothalamic hamartoma: a paradigm/model for studying the onset of puberty.

  title={Hypothalamic hamartoma: a paradigm/model for studying the onset of puberty.},
  author={Heike Jung and A S Parent and Sergio R. Ojeda},
  journal={Endocrine development},
This article discusses the potential mechanisms by which hypothalamic hamartomas (HHs) are formed and cause precocious puberty. The hypothesis is presented suggesting that HHs accelerate sexual development by producing bioactive substances that mimic - in an accelerated time-course - the cascade of events underlying the normal initiation of puberty. It is also proposed that because HHs contain key transcriptional and signaling networks required to initiate and sustain a pubertal mode of… CONTINUE READING
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