Hypothalamic excitatory amino acid system during sexual maturation in female rats

  title={Hypothalamic excitatory amino acid system during sexual maturation in female rats},
  author={Jaime A. Moguilevsky and Silvia Carbone and Berta Szwarcfarb and Dora Rondina and Pablo A. Scacchi},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
Changes in the sensitivity of gonadotrophin axis to leptin during sexual maturation in female rats.
It is clearly demonstrated that leptin has stimulatory effect on gonadotrophin axis been higher in prepubertal than in peripuberal rats, and these differences are connected with the maturation of the neuroendocrine mechanisms involved in the regulatory action of leptin on the gonadOTrophins axis.
Changes in the effect of testosterone on hypothalamic nitric oxide synthetase during sexual maturation. Its relationship with GnRH release.
It is clearly demonstrated that testosterone has an inhibitory effect on hypothalamic NOS activity in prepubertal rats while it did not affect the concentration of this neurotransmitter system in peripuberal rats.
Effect of Leptin on LH Levels and Hypothalamic Release of GnRH. Its Relationship with the Hypothalamic Neurotransmitter Amino Acids System in Adult Male Rats
Results indicate that leptin has an inhibitory effect on the GnRH–LH axis in adult male rats and this effect appears to be connected with an inhibition of hypothalamic release of GLU (the excitatory amino acid) and a stimulatory effect on GABA release (the inhibitory amino acid).
Regulation of Norepinephrine in the Medial Preoptic Area of Siberian Hamsters by Gonadal Steroids
Investigation of the effects of photoperiod and steroid levels on norepinephrine (NE), one of the major neurochemical regulators of gonadotropin-releasing hormone (GnRH) function, suggests thatPhotoperiodic modulation of GnRH neuronal function by NE is achieved largely through the indirect effects of photography on circulating gonadal steroids.
Neurobiological mechanisms of the onset of puberty in primates.
Developmental changes in several neurotransmitter systems controlling pulsatile LHRH release are extensively reviewed and it appears that the reduction in tonic GABA inhibition allows an increase in the release of glutamate as well as other neurotransmitters, which contributes to the increase in pubertal L HRH release.
O R I G I N A L R E P O R T Changes in the Effect of Testosterone on Hypothalamic Nitric Oxide Synthetasa During Sexual Maturation. Its Relationship with GnRH Release
It is proposed that the changes here described are connected with maturational modifications in the sexual hormones on-GnRH axis connected with the onset of puberty.


Sexual maturation modifies the catecholaminergic control of gonadotrophin secretion and the effect of ovarian hormones on hypothalamic neurotransmitters in female rats.
alpha-Methyl-p-tyrosine (alpha-MT), a competitive inhibitor of tyrosine hydroxylase, was used to block the synthesis of hypothalamic catecholamines in immature female rats of 14, 16 and 30 days of
Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids.
The in vitro release of GnRH from the hypothalamus showed a maximal increase in animals sacrificed 7.5 min after NMDA injection, while serum LH levels rose concomitantly, and the permissive effect of glycine on GnRH response to NMDA was 2.7-fold more important using glycine concentrations of 0.01 microM than when concentrations greater than or equal to 100 microM were used.
Effect of the serotoninergic system on luteinizing hormone secretion in prepubertal female rats.
The results suggest that the serotoninergic system has an inhibitory effect on the development of the positive feed-back of ovarian steroids on LH secretion, that could be representative of a regulatory participation of serotonin in the onset of puberty.
Development of estradiol-positive feedback on luteinizing hormone release in the female rat: a quantitative study.
Experiments were conducted to study, in a quantitative manner, the development of estradiol (E2)-positive feedback on LH release in the female rat. A Silastic capsule (20 mm in length/100 g BW)
N-methyl-D,L-aspartate elicits hypothalamic gonadotropin-releasing hormone release in prepubertal male rhesus monkeys (Macaca mulatta).
The apparent dormancy of hypothalamic GnRH neurons, which is characteristic of prepubertal development in higher primates and underlies the protracted delay in the onset of puberty in these species, may be readily terminated by application of a generalized neural excitation.
Activation of luteinizing hormone-releasing hormone release advances the onset of female puberty.
The juvenile-peripubertal transition period in the female rat is associated with an ovarian-independent afternoon increase in the amplitude of plasma luteinizing hormone (LH) pulses, and the LHRH neuronal system can be precociously activated by the episodic administration of an excitatory amino acid analog that is known to interact with specific brain receptors.
A role for N-methyl-D-aspartate (NMDA) receptors in the control of LH secretion and initiation of female puberty.
It is demonstrated that blockade of NMDA receptors can prevent the development of enhanced LH secretion in female rats undergoing sexual maturation, and this results support the view that activation ofNMDA receptors significantly contributes to the physiological initiation of the pubertal process.
Excitatory amino acid neurotransmission.