Hypothalamic dysfunction in overtrained athletes.

@article{Barron1985HypothalamicDI,
  title={Hypothalamic dysfunction in overtrained athletes.},
  author={Jeffrey L. Barron and Timothy David Noakes and W Levy and C E Smith and Robert P. Millar},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1985},
  volume={60 4},
  pages={
          803-6
        }
}
Some athletes who undertake strenuous training programs for a prolonged period of time develop the overtraining syndrome. The pathophysiology of the condition is unknown. Hypothalamic-pituitary function was studied by determining the hormonal responses to insulin-induced hypoglycemia in five asymptomatic male marathon runners during a 4-month period in which they ran 42-, 56-, and 92-km races and in four overtrained male athletes. The response of the asymptomatic runners was not different when… 

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References

SHOWING 1-10 OF 17 REFERENCES

Menstrual dysfunction in distance runners.

TLDR
It is concluded that menstrual dysfunction in distance runners is a real phenomenon and presumably this is related to decreased percentage of body fat and/or minimal ovarian function secondary to diminished hypothalamic or pituitary hormone secretion.

Hypothalamic amenorrhea in runners of normal body composition.

Three amenorrheic runners of normal body weight, in whom organic disease had been excluded, were found to exhibit: (1) normal body composition, (2) low baseline concentrations of serum LH and normal

The effects of exercise on pubertal progression and reproductive function in girls.

  • M. Warren
  • Medicine
    The Journal of clinical endocrinology and metabolism
  • 1980
TLDR
Energy drain may have an important modulatory effect on the hypothalamic pituitary set point at puberty and, in combination with low body weight, may prolong the prepubertal state and induce amenorrhea.

Exercise, Body Weight, and Amenorrhea in Professional Ballet Dancers.

TLDR
Professional female ballet dancers studied by means of a gynecological questionnaire found that menstrual dysfunction was related to both strenuous physical exercise and diminished body weight, and it was reversible, often disappearing with significant weight gain or intervals of less intense exercise.

Regulation of the adrenocortical response to insulin-induced hypoglycemia.

TLDR
Although the direct response to hypoglycemia was abolished by pentobarbital, the magnitude of the corticosteroid response to a surgical stimulus was increased in markedly hypoglycemic rats compared to that in euglycemic controls, suggesting that low glucose levels may act at some point in the final common pathway to augment hormonal responses to other stim...

A simple radioimmunoassay for plasma cortisol.

  • J. SethL. M. Brown
  • Medicine, Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 1978

Exercise in Education and Medicine

TLDR
There seems to be at least one striking exception to the general rule of the easy adaptation of other forms of animal life to the Hawaiian climate, in the case of the eastern oyster, which has repeatedly been introduced, but which has never become acclimatized.

The science of swimming

Delayed menarche and amenorrhea in ballet dancers.