Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids.

  title={Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids.},
  author={Niels Vrang and Philip Just Larsen and Mads Tang-Christensen and Leif Kongskov Larsen and Peter H Kristensen},
  journal={Brain research},
  volume={965 1-2},
Cocaine-amphetamine-regulated transcript (CART) is one of the most abundantly expressed mRNAs in the rat hypothalamus. CART mRNA expression in the arcuate nucleus has been shown to be regulated by leptin, and CART peptides have been implicated in feeding behavior and in the regulation of the HPA-axis. To more fully understand the physiological regulation of CART gene expression, we have examined the effects of adrenalectomy and different types of glucocorticoid substitution (corticosterone and… CONTINUE READING
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