Hypothalamic arousal regions are activated during modafinil-induced wakefulness.

@article{Scammell2000HypothalamicAR,
  title={Hypothalamic arousal regions are activated during modafinil-induced wakefulness.},
  author={Thomas E Scammell and Ivy V Estabrooke and Madeline McCarthy and Richard M. Chemelli and Masashi Yanagisawa and Merl Miller and Clifford B. Saper},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 22},
  pages={8620-8}
}
Modafinil is an increasingly popular wake-promoting drug used for the treatment of narcolepsy, but its precise mechanism of action is unknown. To determine potential pathways via which modafinil acts, we administered a range of doses of modafinil to rats, recorded sleep/wake activity, and studied the pattern of neuronal activation using Fos immunohistochemistry. To contrast modafinil-induced wakefulness with spontaneous wakefulness, we administered modafinil at midnight, during the normal… CONTINUE READING
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