Hypothalamic appetite-regulating neuropeptide mRNA levels in cachectic nude mice bearing human tumor cells.

@article{Naraashizawa2001HypothalamicAN,
  title={Hypothalamic appetite-regulating neuropeptide mRNA levels in cachectic nude mice bearing human tumor cells.},
  author={N Nara-ashizawa and Toshihiko Tsukada and Kouji Maruyama and Yasuto Akiyama and Naoko Kajimura and Koichi Nagasaki and Toshihiko Iwanaga and Ken Yamaguchi},
  journal={Metabolism: clinical and experimental},
  year={2001},
  volume={50 10},
  pages={1213-9}
}
We previously reported that the human melanoma cell line, SEKI, induces severe weight loss in nude mice. In the present study, we examined the expression of weight-regulating neuropeptide mRNAs in the hypothalamus of this cancer cachectic model by using a sensitive quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method and in situ hybridization. mRNA levels of neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH) in the whole hypothalamus were elevated… CONTINUE READING

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