Hypothalamic alterations in fetuses of high fat diet-fed obese female rats.

@article{Gupta2009HypothalamicAI,
  title={Hypothalamic alterations in fetuses of high fat diet-fed obese female rats.},
  author={Anshu Gupta and Malathi Srinivasan and Supaporn Thamadilok and Mulchand S. Patel},
  journal={The Journal of endocrinology},
  year={2009},
  volume={200 3},
  pages={293-300}
}
The offspring of high fat (HF) diet-fed rats display increased body weight during adulthood. However, it is not known whether the changes in appetite regulation in these animals occur in utero or postnatally. We investigated the effects of maternal obesity induced by a HF diet prior to and during pregnancy on leptin and insulin signaling and the expression of orexigenic and anorexigenic peptides in term fetal hypothalami. The consumption of a HF diet prior to and during pregnancy resulted in… CONTINUE READING
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