Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173.

@article{Stein2016HypothalamicAO,
  title={Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173.},
  author={Lauren Stein and C. Tullock and Stacy K Mathews and D. Garcia-Galiano and C. Elias and W. K. Samson and G. Yosten},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2016},
  volume={311 3},
  pages={
          R489-96
        }
}
  • Lauren Stein, C. Tullock, +4 authors G. Yosten
  • Published 2016
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
Sexual maturation and maintenance of reproductive function are regulated by neurohormonal communication between the hypothalamus, pituitary, and gonads (referred to as the HPG axis). Phoenixin (PNX) is a newly identified, endogenous peptide abundantly produced in the hypothalamus and shown to be an important mediator of ovarian cyclicity. However, the underlying mechanisms by which phoenixin functions within the HPG axis are unknown. Previous in vitro studies demonstrated a direct action of PNX… Expand
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