Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

@article{VanDenEede2007HypothalamicPituitaryAdrenalAF,
  title={Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome},
  author={Filip Van Den Eede and Greta Moorkens and Boudewijn van Houdenhove and Paul R Cosyns and Stephan Claes},
  journal={Neuropsychobiology},
  year={2007},
  volume={55},
  pages={112 - 120}
}
There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS), despite the negative studies and methodological difficulties. In this review, we focus on challenge studies and on the role of the HPA axis in the pathogenesis of CFS. Mild hypocortisolism, blunted adrenocorticotropin response to stressors and enhanced negative feedback sensitivity to glucocorticoids are the main findings. Several underlying… Expand
A Review of Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome
TLDR
Given the interindividual variation in the effectiveness of existing biological and psychological treatments, the need for novel treatment strategies such as those which target the HPA axis is clear. Expand
HPA-axis dysfunction in chronic fatigue syndrome: clinical implications.
TO THE EDITOR: There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS). Mild hypocortisolism, bluntedExpand
Does hypothalamic-pituitary-adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system?
TLDR
This comprehensive hypothesis on HPA axis hypofunction in CFS may stimulate diagnostic refinement of the illness, inform treatment approaches and suggest directions for future research, particularly focusing on the neuroendocrine-immune interface and possible links between CFS, early and recent life stress, and depression. Expand
Combined dexamethasone/corticotropin-releasing factor test in chronic fatigue syndrome
TLDR
CFS is globally associated with reduced cortisol responses in the combined low-dose dexamethasone/corticotropin-releasing factor test, but this effect is only clearly present in CFS patients without a history of ELS, which provides further support for an enhanced glucocorticoid negative feedback and/or a reduced central HPA axis drive in C FS. Expand
Fibromyalgia and chronic fatigue: the underlying biology and related theoretical issues.
TLDR
This chapter will focus on inflammatory and oxidative stress pathways and on the neuroendocrine system, which have been more commonly examined and suggest a role for the hypothalamic-pituitary-adrenal axis and cortisol in the pathogenesis of these syndromes. Expand
Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways
TLDR
Findings show that activation of immune-inflammatory and O&NS pathways in ME/CFS are probably not secondary to HPA axis hypoactivity and thatactivation of these pathways may underpin HPA Axis hypofunction in ME /CFS. Expand
Model-Based Therapeutic Correction of Hypothalamic-Pituitary-Adrenal Axis Dysfunction
TLDR
A model-based predictive control (MPC) methodology is used to estimate robust treatment courses for displacing the HPA axis from an abnormal hypocortisol steady state back to a healthy cortisol level. Expand
Effects of early childhood trauma on hypothalamic–pituitary–adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome
TLDR
Findings of this study suggest that emotional neglect is associated with blunted HPA axis reactivity, congruent with the assumption that CFS may reflect loss of adaptability of the neuroendocrine stress response system in at least a subgroup of patients. Expand
Hypothalamic Dysfunction and Multiple Sclerosis: Implications for Fatigue and Weight Dysregulation
TLDR
Three hypothalamic mechanisms of fatigue in multiple sclerosis are discussed: general hypothalamic-pituitary-adrenal axis hyperactivity, disordered orexin neurotransmission, and potential mechanisms of weight dysregulation caused by hypothalamic dysfunction. Expand
Chronic fatigue syndrome--a neuroimmunological model.
TLDR
It is argued that CFS pathogenesis lies in the influence of peripheral inflammatory events on the brain and the unique immunophysiology of the central nervous system and the use of anti-TNF biological agents as a reliable and effective treatment approach to CFS. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 100 REFERENCES
The HPA axis and the genesis of chronic fatigue syndrome
  • A. Cleare
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
  • 2004
TLDR
It is presented the case that there is no specific change to the HPA axis in CFS and that the observed changes are of multifactorial aetiology, with some factors occurring as a consequence of the illness. Expand
The low dose ACTH test in chronic fatigue syndrome and in health
TLDR
Whether the 1 μg ACTH test would support such a dysregulation in CFS is established and the relative novelty of this test in clinical practice and the uncertainty with regard to appropriate cut‐off values for normality are compared. Expand
Evidence for and Pathophysiologic Implications of Hypothalamic‐Pituitary‐Adrenal Axis Dysregulation in Fibromyalgia and Chronic Fatigue Syndrome
TLDR
It is established that impaired activation of the hypothalamic‐pituitary‐adrenal (HPA) axis is an essential neuroendocrine feature of Chronic fatigue syndrome and this finding provides an important clue to the development of more effective treatment to this disabling condition. Expand
The neuroendocrinology of chronic fatigue syndrome.
TLDR
It is suggested that more prospective cohort studies be undertaken in groups at high risk for CFS, that patients with CFS are followed up into recovery, and that multidimensional assessments are undertaken to unravel the influence of the various confounding factors on the observed endocrine changes in CFS. Expand
Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.
TLDR
The extent of opioid inhibition of HPA activity in CFS is investigated as a possible explanation for the reputed HPA hypofunctioning in patients with CFS and naloxone mediated activation of the HPA is attenuated. Expand
Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome.
TLDR
It is suggested that fibromyalgia is related to a neuroendocrine disorder characterized by hyperreactive pituitary ACTH release and a relative adrenal hyporesponsiveness, which might serve clinically as an explanation for the reduced aerobic capacity and impaired muscle performance these patients display. Expand
Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome.
TLDR
Although it cannot definitively account for the etiology of the mild glucocorticoid deficiency seen in chronic fatigue syndrome patients, the enhanced adrenocortical sensitivity to exogenous ACTH and blunted ACTH responses to oCRH are incompatible with a primary adrenal insufficiency. Expand
Abnormalities in response to vasopressin infusion in chronic fatigue syndrome
TLDR
Evidence is provided of reduced hypothalamic CRH secretion in patients with chronic fatigue syndrome by measuring the ACTH and cortisol response to a one hour infusion of arginine vasopressin in 19 patients and 19 age and sex matched healthy volunteers. Expand
Hypothalamic-Pituitary-Adrenal Axis Reactivity in Chronic Fatigue Syndrome and Health Under Psychological, Physiological, and Pharmacological Stimulation
TLDR
The results suggest that CFS patients are capable of mounting a sufficient cortisol response under different types of stress but that on a central level subtle dysregulations of the HPA axis exist. Expand
Associations between neuroendocrine responses to the Insulin Tolerance Test and patient characteristics in chronic fatigue syndrome.
TLDR
The results of a strong association between the integrated ACTH response and the duration of C FS emphasizes the need to consider factors known to be risk factors for the chronicity of CFS symptoms, such as profound inactivity, deconditioning and sleep abnormalities, as possible candidates for secondary causes of neuroendocrine dysregulations in CFS. Expand
...
1
2
3
4
5
...