Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

  title={Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome},
  author={F. van den Eede and G. Moorkens and B. van Houdenhove and P. Cosyns and S. Claes},
  pages={112 - 120}
  • F. van den Eede, G. Moorkens, +2 authors S. Claes
  • Published 2007
  • Medicine, Psychology
  • Neuropsychobiology
  • There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS), despite the negative studies and methodological difficulties. In this review, we focus on challenge studies and on the role of the HPA axis in the pathogenesis of CFS. Mild hypocortisolism, blunted adrenocorticotropin response to stressors and enhanced negative feedback sensitivity to glucocorticoids are the main findings. Several underlying… CONTINUE READING
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