Hypothalamic-Pituitary-Adrenal Axis Dysfunction and Illness Progression in Bipolar Disorder

  title={Hypothalamic-Pituitary-Adrenal Axis Dysfunction and Illness Progression in Bipolar Disorder},
  author={Gabriel Rodrigo Fries and Mirela Paiva Vasconcelos-Moreno and Carolina Gubert and B{\'a}rbara Tietb{\"o}hl Martins Quadros dos Santos and Juliana Sartori and B{\'a}rbara Eisele and P{\^a}mela Ferrari and Adam Fijtman and Jo{\"e}lle R{\"u}egg and Nils Christian Gassen and Fl{\'a}vio Kapczinski and Theo Rein and M{\'a}rcia Kauer-Sant’Anna},
  booktitle={The international journal of neuropsychopharmacology},
BACKGROUND Impaired stress resilience and a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis are suggested to play key roles in the pathophysiology of illness progression in bipolar disorder (BD), but the mechanisms leading to this dysfunction have never been elucidated. This study aimed to examine HPA axis activity and underlying molecular mechanisms in patients with BD and unaffected siblings of BD patients. METHODS Twenty-four euthymic patients with BD, 18 siblings of BD patients… CONTINUE READING
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