Hypothalamic Obesity: The Myth of the Ventromedial Nucleus

@article{Gold1973HypothalamicOT,
  title={Hypothalamic Obesity: The Myth of the Ventromedial Nucleus},
  author={Richard M. Gold},
  journal={Science},
  year={1973},
  volume={182},
  pages={488 - 490}
}
  • R. M. Gold
  • Published 2 November 1973
  • Biology, Psychology
  • Science
Lesions restricted to the ventromedial nucleus of the hypothalamus were neither necessary nor sufficient for, and did not contribute to, the production of hypothalamic obesity. Hypothalamic lesions and knife cuts that do produce obesity damage the nearby ventral noradrenergic bundle or its terminals. 
Obesity, overeating, and rapid gastric emptying in rats with ventromedial hypothalamic lesions.
Measurements confirm the quantitative theoretical prediction that the autonomic nonendocrine abnormality of rapid daytime gastric emptying is the major primary cause of the obesity resulting from
Catecholamines in some hypothalamic and telencephalic nuclei of food deprived rats.
TLDR
The influence of 48 h food deprivation on the levels of catecholamines was investigated in different hypothalamic and telencephalic nuclei of the rat brain and observed a statistically significant decrease of NA and DA in the ventromedial nucleus and the decrease in the arcuate nucleus.
Multiple knife cuts between the medial and lateral hypothalamus in the rat: a reevaluation of hypothalamic feeding circuitry.
TLDR
Findings indicate that the feeding inhibitory fibers responsible for the hyperphagia syndrome do not project from the VMH to the LH, and this calls for a reevaluation of hypothalamic circuitry.
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.
TLDR
The results demonstrate that a discrete set of hypothalamic pathways may underlie leptin's autonomic, endocrine, and behavioral effects and provide an anatomic substrate for integration of metabolic and circadian information to regulate the hypothalamo-pituitary axis.
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  • R. M. Gold
  • Biology, Psychology
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