Hypothalamic KATP channels control hepatic glucose production
@article{Pocai2005HypothalamicKC, title={Hypothalamic KATP channels control hepatic glucose production}, author={A. Pocai and T. Lam and R. Guti{\'e}rrez-Ju{\'a}rez and S. Obici and G. Schwartz and J. Bryan and L. Aguilar-Bryan and L. Rossetti}, journal={Nature}, year={2005}, volume={434}, pages={1026-1031} }
Obesity is the driving force behind the worldwide increase in the prevalence of type 2 diabetes mellitus. Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepatic gluconeogenesis. The medial hypothalamus is a major integrator of nutritional and hormonal signals, which play pivotal roles not only in the regulation of energy balance but also in the modulation of liver glucose output. Bidirectional changes in hypothalamic insulin signalling therefore result in parallel… CONTINUE READING
557 Citations
The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism.
- Chemistry, Medicine
- Advances in nutrition
- 2016
- 6
- PDF
Central insulin-mediated regulation of hepatic glucose production [Review].
- Chemistry, Medicine
- Endocrine journal
- 2016
- 26
- PDF
Control of hepatic glucose metabolism by islet and brain
- Medicine
- Diabetes, obesity & metabolism
- 2014
- 39
- Highly Influenced
Regulation of hepatic glucose metabolism in health and disease
- Medicine
- Nature Reviews Endocrinology
- 2017
- 274
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
- Biology, Medicine
- Endocrinology
- 2009
- 142
- PDF
Hypothalamic Leucine Metabolism Regulates Liver Glucose Production
- Biology, Medicine
- Diabetes
- 2011
- 51
- PDF
Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats.
- Biology, Medicine
- American journal of physiology. Endocrinology and metabolism
- 2007
- 25
- PDF
References
SHOWING 1-10 OF 32 REFERENCES
Hypothalamic insulin signaling is required for inhibition of glucose production
- Chemistry, Medicine
- Nature Medicine
- 2002
- 810
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
- Chemistry, Medicine
- Nature
- 1997
- 622
Disruption of Sur2-containing KATP channels enhances insulin-stimulated glucose uptake in skeletal muscle
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2001
- 112
- PDF
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
- Biology, Medicine
- Nature
- 2004
- 1,457
- PDF
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
- Biology, Medicine
- Nature Neuroscience
- 2002
- 632
Important role of the hepatic vagus nerve in glucose uptake and production by the liver.
- Medicine
- Metabolism: clinical and experimental
- 2000
- 65
Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.
- Biology, Medicine
- Diabetes
- 2000
- 142
- PDF
Central administration of oleic acid inhibits glucose production and food intake.
- Chemistry, Medicine
- Diabetes
- 2002
- 599
- PDF