• DOI:10.1038/nature03439
Corpus ID: 4414624

Hypothalamic KATP channels control hepatic glucose production

@article{Pocai2005HypothalamicKC,
  title={Hypothalamic KATP channels control hepatic glucose production},
  author={A. Pocai and T. K. Lam and R. Guti{\'e}rrez-Ju{\'a}rez and S. Obici and G. Schwartz and J. Bryan and L. Aguilar-Bryan and L. Rossetti},
  journal={Nature},
  year={2005},
  volume={434},
  pages={1026-1031}
}

• A. Pocai, T. K. Lam, +5 authors L. Rossetti
• Published 2005
• Biology, Medicine
• Nature

Obesity is the driving force behind the worldwide increase in the prevalence of type 2 diabetes mellitus. Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepatic gluconeogenesis. The medial hypothalamus is a major integrator of nutritional and hormonal signals, which play pivotal roles not only in the regulation of energy balance but also in the modulation of liver glucose output. Bidirectional changes in hypothalamic insulin signalling therefore result in parallel… Expand

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