Hypothalamic GPR40 Signaling Activated by Free Long Chain Fatty Acids Suppresses CFA-Induced Inflammatory Chronic Pain

@inproceedings{Nakamoto2013HypothalamicGS,
  title={Hypothalamic GPR40 Signaling Activated by Free Long Chain Fatty Acids Suppresses CFA-Induced Inflammatory Chronic Pain},
  author={Kazuo Nakamoto and Takashi Nishinaka and Naoya Sato and Mitsumasa Mankura and Yutaka Koyama and Fumiyo Kasuya and Shogo Tokuyama},
  booktitle={PloS one},
  year={2013}
}
GPR40 has been reported to be activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). However, reports studying functional role of GPR40 in the brain are lacking. The present study focused on the relationship between pain regulation and GPR40, investigating the functional roles of hypothalamic GPR40 during chronic pain caused using a complete Freund's adjuvant (CFA)-induced inflammatory chronic pain mouse model. GPR40 protein expression in the hypothalamus was transiently… CONTINUE READING

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