Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

@article{Rahmouni2009HypothalamicEM,
  title={Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin},
  author={Kamal Rahmouni and Curt D. Sigmund and William Geoffrey Haynes and Allyn L. Mark},
  journal={Diabetes},
  year={2009},
  volume={58},
  pages={536 - 542}
}
OBJECTIVE Leptin is an adipocyte hormone that plays a major role in energy balance. Leptin receptors in the hypothalamus are known to signal via distinct mechanisms, including signal transducer and activator of transcription-3 (STAT3) and phosphoinositol-3 kinase (PI 3-kinase). Here, we tested the hypothesis that extracellular signal-regulated kinase (ERK) is mediating leptin action in the hypothalamus. RESEARCH DESIGN AND METHODS Biochemical, pharmacological, and physiological approaches… CONTINUE READING
69 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Central nervous system control of food intake

  • MW Schwartz, SC Woods, D Jr.Porte, RJ Seeley, DG Baskin
  • Nature 404:661-671,
  • 2000
Highly Influential
9 Excerpts

Similar Papers

Loading similar papers…