Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

@article{Ramot2017HypothalamicCI,
  title={Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress},
  author={Assaf Ramot and Zhiying Jiang and Jin-bin Tian and Tali Nahum and Yael Kuperman and Nicholas J. Justice and Alon Chen},
  journal={Nature Neuroscience},
  year={2017},
  volume={20},
  pages={385-388}
}
The hypothalamic–pituitary–adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic–pituitary–adrenal axis regulation that prepares the organism for successive exposure to stressful… 

Central Neuroepigenetic Regulation of the Hypothalamic-Pituitary-Adrenal Axis.

  • A. DickN. Provençal
  • Psychology, Biology
    Progress in molecular biology and translational science
  • 2018

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.

This review focuses on the physiology of CRF-related peptides and their cognate receptors and describes the major molecular features covering aspects of gene expression and regulation, structural properties, and molecular interactions, as well as mechanisms of signal transduction and their surveillance.

Role of the paraventricular nucleus of the hypothalamus in sleep–wake regulation

Emerging anatomical and neural mechanisms for sleep–wake regulation in the paraventricular nucleus of the hypothalamus are reviewed to support its essential role in the promotion and maintenance of wakefulness.
...

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