Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

  title={Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress},
  author={Assaf Ramot and Zhiying Jiang and Jin-bin Tian and Tali Nahum and Yael Kuperman and Nicholas J. Justice and Alon Chen},
  journal={Nature Neuroscience},
The hypothalamic–pituitary–adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic–pituitary–adrenal axis regulation that prepares the organism for successive exposure to stressful… 

Central Neuroepigenetic Regulation of the Hypothalamic-Pituitary-Adrenal Axis.

  • A. DickN. Provençal
  • Psychology, Biology
    Progress in molecular biology and translational science
  • 2018

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.

This review focuses on the physiology of CRF-related peptides and their cognate receptors and describes the major molecular features covering aspects of gene expression and regulation, structural properties, and molecular interactions, as well as mechanisms of signal transduction and their surveillance.

Role of the paraventricular nucleus of the hypothalamus in sleep–wake regulation

Emerging anatomical and neural mechanisms for sleep–wake regulation in the paraventricular nucleus of the hypothalamus are reviewed to support its essential role in the promotion and maintenance of wakefulness.



Neural regulation of endocrine and autonomic stress responses

The survival and well-being of all species requires appropriate physiological responses to environmental and homeostatic challenges, so that the respective contributions of the neuroendocrine and autonomic systems are tuned in accordance with stressor modality and intensity.

Region-specific roles of the corticotropin-releasing factor–urocortin system in stress

A more complex picture has emerged that suggests that there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.

Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin

It is reported here that pretreatment with a vasopressin antagonist decreases the plasma ACTH levels of ether-stressed rats in later (10–20 min), but not earlier (0–10 min), phases of ether stress, which supports a role of CRF, catecholamines and vasopressing factor in mediating ACTH release by ether stress.

When Not Enough Is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-Related Disorders

Neuroendocrine data provide evidence of insufficient glucocorticoid signaling in stress-related neuropsychiatric disorders, including alterations in behavior, insulin sensitivity, bone metabolism, and acquired immune responses.

Bottomed out: metabolic significance of the circadian trough in glucocorticoid concentrations

Chronic mild stress, by overriding the normal mineralocorticoid receptor-mediated corticosteroid feedback regulation of trough CRF and ACTH secretion, facilitates development of the metabolic syndrome.

Brain corticosteroid receptor balance in health and disease.

The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.

Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances

Significant increased CRF mRNA levels in the PVN of the depressed patients were found, accompanied by a significantly increased expression of four genes involved in the activation of CRF neurons, that is, CRFR1, estrogen receptor-α, AVPR1A and mineralocorticoid receptor, which raises the possibility that a disturbed balance in the production of receptors may contribute to theactivation of the HPA axis in depression.