Hypotensive effects of lithospermic acid B isolated from the extract of Salviae miltiorrhizae Radix in the rat.

@article{Kamata1994HypotensiveEO,
  title={Hypotensive effects of lithospermic acid B isolated from the extract of Salviae miltiorrhizae Radix in the rat.},
  author={Katsuo Kamata and Mariko Noguchi and Maiko Nagai},
  journal={General pharmacology},
  year={1994},
  volume={25 1},
  pages={69-73}
}
1. The in vivo and in vitro effects of lithospermic acid B (LSA-B), which was extracted from Salviae miltiorrhizae Radix, on vascular relaxation responses were examined in rats. 2. Intravenous injection of LSA-B (10-30 mg/kg) decreased the blood pressure in a dose-dependent manner. 3. In perfused mesenteric arterial bed precontracted with methoxamine (10(-5) M), LSA-B (10(-5) - 10(-3) M) produced a concentration-dependent relaxation. 4. Vasodilator response of the mesentery in response to LSA-B… CONTINUE READING
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