Hypotensive effect of butein via the inhibition of angiotensin converting enzyme.

@article{Kang2003HypotensiveEO,
  title={Hypotensive effect of butein via the inhibition of angiotensin converting enzyme.},
  author={Dae Gill Kang and Yun Cheol Kim and Eun Jin Sohn and Yun mi Lee and An Sook Lee and Ming Hao Yin and Ho Sub Lee},
  journal={Biological & pharmaceutical bulletin},
  year={2003},
  volume={26 9},
  pages={1345-7}
}
Butein (3,4,2',4'-tetrahydroxychalcone), a plant polyphenol, has been known to elucidate endothelium-dependent vasodilation. In the present study, the hypotensive effect of butein and its possible mechanism, especially an angiotensin converting enzyme (ACE) inhibitory effect, were investigated. Intravenous injection of butein lowered the arterial blood pressure of anesthetized rats in a dose-dependent manner. The plasma ACE activities were significantly inhibited by the addition of butein in a… CONTINUE READING

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