Hypotensive effect of angiotensin II after AT1-receptor blockade with losartan.

@article{Matys2000HypotensiveEO,
  title={Hypotensive effect of angiotensin II after AT1-receptor blockade with losartan.},
  author={Tomasz Matys and Robert Pawlak and Iwona Kucharewicz and Ewa Chabielska and Wlodzimierz Buczko},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2000},
  volume={51 1},
  pages={161-6}
}
Recent data suggest that hypotensive effect of losartan may not be attributed solely to AT1-receptor blockade, but also to excessive AT2 or other receptors stimulation by elevated angiotensin II and its derivative peptides. Therefore in the present study we examined the effect of angiotensin II on mean blood pressure after AT -receptor blockade with losartan. Male Wistar rats were anaesthetised and received injection of either losartan (30 mg/kg, 1 ml/kg, i.v.) or saline (the same volume and… CONTINUE READING