Hypotensive and cardio-chronotropic constituents of Tinospora crispa and mechanisms of action on the cardiovascular system in anesthetized rats.

@article{Praman2012HypotensiveAC,
  title={Hypotensive and cardio-chronotropic constituents of Tinospora crispa and mechanisms of action on the cardiovascular system in anesthetized rats.},
  author={Siwaporn Praman and M. Mulvany and D. Williams and R. Andersen and C. Jansakul},
  journal={Journal of ethnopharmacology},
  year={2012},
  volume={140 1},
  pages={
          166-78
        }
}
ETHNOPHARMACOLOGICAL RELEVANCE Tinospora crispa has been used in folkloric medicine for the control of blood pressure. We previously found that an extract of Tinospora crispa stems decreased the mean arterial blood pressure (MAP) with a transient decrease, followed by an increase in the heart rate (HR) in rats. AIM OF THE STUDY To identify the active components of the Tinospora crispa extract and investigate the mechanisms of action on blood pressure and heart rate in anesthetized rats… Expand
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